Drew Miller is Back In Da' House
Welcome back Drew!
'C' is for Connor, 'C' is for Clinton, 'C' is for carbon, 'C' is for computer
One of the problems we were aiming to address is that there is a lack of comprehensive, usable web resources for people and groups writing about bills and issues in Congress. The Library of Congress website, Thomas, doesn't do nearly enough to make Congressional information accessible -- meaning that political bloggers didn't have anywhere helpful to link when discussing Congress, that there wasn't a way for their readers to get the "big picture" behind an issue. The lack of public knowledge about what's really happening in Congress breeds apathy about political change in general.
OpenCongress helps close the information gap between political insiders and the public by bringing together official government information from Thomas (by way of GovTrack.us), news articles from Google News, blog posts from Technorati, campaign contribution data from OpenSecrets.org, and more -- to give you the real story behind what's happening in Congress.
Labels: Technology, Transparency
Labels: Technology
It sounds almost too good to be true: a cheap and simple drug that kills almost all cancers by switching off their “immortality”. The drug, dichloroacetate (DCA), has already been used for years to treat rare metabolic disorders and so is known to be relatively safe.
It also has no patent, meaning it could be manufactured for a fraction of the cost of newly developed drugs.
Evangelos Michelakis of the University of Alberta in Edmonton, Canada, and his colleagues tested DCA on human cells cultured outside the body and found that it killed lung, breast and brain cancer cells, but not healthy cells. Tumours in rats deliberately infected with human cancer also shrank drastically when they were fed DCA-laced water for several weeks.
DCA attacks a unique feature of cancer cells: the fact that they make their energy throughout the main body of the cell, rather than in distinct organelles called mitochondria. This process, called glycolysis, is inefficient and uses up vast amounts of sugar.
Michelakis suggests that the switch to glycolysis as an energy source occurs when cells in the middle of an abnormal but benign lump don’t get enough oxygen for their mitochondria to work properly (see diagram). In order to survive, they switch off their mitochondria and start producing energy through glycolysis.
Crucially, though, mitochondria do another job in cells: they activate apoptosis, the process by which abnormal cells self-destruct. When cells switch mitochondria off, they become “immortal”, outliving other cells in the tumour and so becoming dominant. Once reawakened by DCA, mitochondria reactivate apoptosis and order the abnormal cells to die.
“The results are intriguing because they point to a critical role that mitochondria play:
they impart a unique trait to cancer cells that can be exploited for cancer therapy,” says Dario Altieri, director of the University of Massachusetts Cancer Center in Worcester.
The next step is to run clinical trials of DCA in people with cancer. These may have to be funded by charities, universities and governments: pharmaceutical companies are unlikely to pay because they can’t make money on unpatented medicines. The pay-off is that if DCA does work, it will be easy to manufacture and dirt cheap.
Paul Clarke, a cancer cell biologist at the University of Dundee in the UK, says the findings challenge the current assumption that mutations, not metabolism, spark off cancers. “The question is: which comes first?” he says.
Labels: Technology
Labels: Media, Technology
With the midterm election around the corner, here's a wacky idea you won't often hear from our elected leaders: We should raise the tax on gasoline. Not quickly, but substantially. I would like to see Congress increase the gas tax by $1 per gallon, phased in gradually by 10 cents per year over the next decade. Campaign consultants aren't fond of this kind of proposal, but policy wonks keep pushing for it.
Labels: Blogger
PHOENIX — The University of Phoenix became the nation’s largest private university by delivering high profits to investors and a solid, albeit low-overhead, education to midcareer workers seeking college degrees.
But its reputation is fraying as prominent educators, students and some of its own former administrators say the relentless pressure for higher profits, at a university that gets more federal student financial aid than any other, has eroded academic quality.
According to federal statistics and government audits, the university relies more on part-time instructors than all but a few other postsecondary institutions, and its accelerated academic schedule races students through course work in about half the time of traditional universities. The university says that its graduation rate, using the federal standard, is 16 percent, which is among the nation’s lowest, according to Department of Education data. But the university has dozens of campuses, and at many, the rate is even lower.
...
Many students accuse recruiters of misleading them, and the university’s legal troubles trace back to similar accusations of recruitment abuses. In 2003, two enrollment counselors in California filed a whistle-blower lawsuit in federal court accusing the university of paying them based on how many students they enrolled, a violation of a federal rule.
After the lawsuit was filed, the Department of Education sent inspectors to California and Arizona campuses. The department’s report, which became public in 2004, concluded that the university had provided incentives to recruit unqualified students and “systematically operates in a duplicitous manner.”
The university paid $9.8 million to settle the matter, while admitting no wrongdoing. But the department’s searing portrait of academic abuse aroused skepticism among many educators.
Those questions are likely to dog the university as it defends itself in the lawsuit, which a district court had dismissed but an appellate court reinstated in September. The university could be forced to repay hundreds of millions of dollars if it loses. It asked the Supreme Court last month to review the appellate ruling, arguing that an adverse outcome in the lawsuit could expose it to “potentially bankrupting liability.”
Labels: Music
Labels: Music
he Iowa Army National Guard has one of the worst equipment shortages of National Guard organizations in the country for responding to large-scale terror attacks or natural disasters, a federal report released Wednesday said.
The U.S. Government Accountability Office, an investigative arm of Congress, said the Iowa National Guard had 42.5 percent of its authorized equipment inventory for nondeployed forces as of November 2006. That was seventh-lowest among the 50 states, the District of Columbia and three U.S. territories.
However, there is no question the global war on terrorism has taken a toll on the Iowa National Guard's equipment inventory. In the fall of 2001, the Iowa Guard had 74 percent of its authorized equipment inventory, Hapgood said.
The federal report said the majority of state national guards have capabilities to handle typical domestic missions, but shortages exist and concerns remain about the ability to respond to large-scale, multistate events. The massive, state-led and federally funded response to Hurricane Katrina illustrates the Guard's important role in such events, the study added.
The Army has budgeted $21 billion between 2005 and 2011 to modernize the Army National Guard and expand its equipment inventory, the GAO report said. However, this equipment may be deployed to meet overseas demands, and the Army has not specified how much equipment will remain in the United States for domestic missions, the study said.
- Hook. A State Department official protected by a Blackwater PSD (personal security detail) convoy was attacked.
- Line. QRF (quick reaction force) ground teams were dispatched from the Green Zone to relieve the convoy. These teams were ambushed. One retreated and the others were halted.
- Sinker. Two Blackwater Boeing Little Birds (small helicopter gunships) were dispatched to provide support. One was shot down and the other was damaged and forced to return to base. Recovery teams found the four bodies (one more died on the other helo that returned to the green zone) from the helicopter crash were stripped of their weapons.
Now it is not good for the Christian’s health to hustle the Aryan brown,
For the Christian riles, and the Aryan smiles and he weareth the Christian down;
And the end of the fight is a tombstone white with the name of the late deceased,
And the epitaph drear: “A Fool lies here who tried to hustle the East.”
Here's a systems view of the escalating tensions between the US and Iran and why it will likely result in war. The current situation is open loop -- an open loop system is one where all participants are regularly adding inputs without any consideration of the output/outcome. Feedback loops, like direct diplomatic contact or the use of international bodies/mediators to adjudicate disputes, that could typically serve to mitigate further deterioration have been intentionally turned off by those that want this conflict to occur. As are result, inputs from allies like Israel and Saudi Arabia (both fearful of growing Iranian power), impetus from guerrillas/militias forcing sectarian conflict, fears over ongoing nuclear development, mutual military preparation for conflict, and a need to assign blame for escalating counter-insurgency failures continue to drive it forward. At some point in the not too distant future, unless the feedback loops are reinstated, the system will inevitably produce an outcome that will force a war.
How do we contain this chaos (?) has become the question upon which the entire global economy rides. The spread of this war would eliminate Iraqi oil production entirely and put at risk the production available from Saudi Arabia, Kuwait, and Iran. It would also set-up the US, which should be the main force for global cooperation, for an extremely hard landing both domestically and internationally, which may take a decade or more to recover from.
The first and foremost approach to doing this is to lessen the potential of state vs. state warfare. A war between the US/Israel and Iran would quickly destabilize every state in the Middle East and allow them to fall prey to open source war like Iraq. The best method for lessening the chance of this war is to open connections with both Iran and Syria (with Syria as the prime target) to reduce their connectivity to non-state groups. This not only reduces internal dynamics (that breathing your own exhaust creates) it can also help to make it more difficult for global guerrillas to generate an attack (another black swan -- I'm thinking of attacks that could do this, are you?) that serves as a pretext for regional war. Other ideas can be found in a report by Daniel Byman and Kenneth Pollack at the Saban Center (Brookings) called "Things Fall Apart: Containing the Spillover from and Iraqi Civil War.". This report is just the start, much more thinking needs to be done.
Labels: 4th Generation Warfare, Iraq
Groundhog Day has been part of the Western calendar since around the fifth century, which means it has survived centuries of Catholicism, the Reformation, the Enlightenment, the Industrial Revolution, and the advent of the agriculture of cloned sheep.
But whether it will survive in an age of global warming was one question — albeit not the biggest one — raised by the awkward coincidence yesterday of Groundhog Day 2007 falling on the same day a report was released by the Intergovernmental Panel on Climate Change of the United Nations.
In fact, both “El Niño” and “global warming” appeared in the official forecast read on Phil’s behalf at 7:28 a.m. yesterday by a spokesman for the Punxsutawney Groundhog Club, an organization loosely affiliated with the Chamber of Commerce of Punxsutawney, Pa., whose usual population of 6,000 swells to around 20,000 for the annual announcement.
“El Niño has caused high winds, heavy snow, ice and freezing temperatures in the West,” the four-legged forecaster began his four-couplet decree. “Here in the East with much mild winter weather we have been blessed.
“Global warming has caused a great debate; this mild winter makes it seem just great,” he continued. “On this Groundhog Day we think of one thing. Will we have winter or will we have spring? On Gobbler’s Knob I see no shadow today. I predict that early spring is on the way.”
In its earliest incarnation, Groundhog Day or something like it was a pagan observance, marking the midpoint between the winter and spring solstices, according to historians.
Burrowing animals like the groundhog were said to have the supernatural ability to foretell an early spring. The observance merged at some point with the Christian holiday of Candlemas, and the tradition embodied in this proverb: “If Candlemas be fair and bright, winter will have another fight. If Candlemas brings cloud and rain, winter won’t come again.”
Labels: Climate Change